It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
In the world of bodybuilding where DNP is most commonly found a dosing of 600mg per day is not uncommon and such a dose can be taken safely; however, while we cannot recommend you ever use DNP to begin with, if you do we would prefer a lower dose of approximately 400mg per day . Remember, it does not take a lot to see any fat burning, no, it doesn’t take much at all and if you get greedy and try to speed the fat loss up you won’t; all you’ll do is severely damage your body. Most will also find 2-3 weeks of use to be the maximal time frame of use; that may not sound like much but when you think about what that short time frame can do it’s mind-blowing. As DNP can burn a full pound of body-fat per day one could easily drop 20lbs of pure fat in that time frame, not 20lbs of bodyweight but 20lbs of pure fat and that is absolutely amazing. For the first time user 300-400mg per day for a 2 week course is the only reasonable course of action and if another 2 week course is needed it is recommended at least 4-5 weeks of no DNP be put in place in-between the two 2 week runs.